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Thus it is apparent that structural rearrangements in LCDR3 may well be linked to those in HCDR3 through the anchorpoints of each CDR and with both affected in some way by mutations occurring with maturation; however as HCDR3 was disordered in the liganded mature CH58 structure (Liao et al., 2013), it is impossible to draw definitive conclusions about HCDR3 and its role in ligand binding.
They are areas where it is impossible to draw clear lines between state, mafia and business.
It is impossible to draw conclusions from individual patients, he said.
It is impossible to draw a distinction between bed and breakfasts and hotels.
So it is impossible to draw conclusions about how the disparity ultimately affected patients' health.
But no matter how noble the effort, it is impossible to draw gold from an empty cauldron.
Unlike the Poisson process, it is impossible to "draw" a picture of the path of a particle undergoing mathematical Brownian motion.
Campaigners say it is impossible to draw definitive causal links between the fall in deaths and the increase in rescue operations.
Perhaps it is impossible to draw a line between being too agnostic about the future and being too assured about it.
Without access to a complete set of data, it is impossible to draw hard statistical conclusions about how much the drugs mattered.
"It is impossible to draw a line of accountability for the things that went wrong on that executive order to Reince," a source close to Priebus said.
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