HA is one of the principal ECM molecules and together with its CD44 cell surface receptor, it is implicated in cancer cell invasion and metastasis [ 62].
AID is a key enzyme for antibody diversification and due to its mutagenic activity outside immunoglobulin loci it is implicated in lymphomagenesis.
It is implicated in many tumours for its role in tumour aggressiveness and angiogenesis.
Tumour endothelial marker-8 (TEM-8) has been found to be selectively up regulated in tumour-associated endothelial cells, it is implicated in tumour specific angiogenesis, but its mechanism in angiogenesis is not defined.
However, it has been published that SEPW1 is strictly correlated with p53; in fact, it is implicated in oxidative modifications of p53, and its knockdown induces cell cycle arrest by increasing p53 [ 18].
It is implicated in the processing of extracellular signals and its absence or misfunctioning lead to a broad variety of serious defects known as ciliopathies.
Its activity is elevated in hormone-independent breast cancer, and it is implicated in enhanced cell survival and chemoresistance in cancer [ 19].
It is implicated in the civilian deaths.
Humanity, as Cardinal Newman put it, is "implicated in some terrible aboriginal calamity".
But its food chain doesn't end there, because the corn itself grows somewhere else, where it is implicated in a whole other set of ecological relationships.
It is implicated in more than twice as many deaths as heroin, and is rivaling or surpassing the tolls of painkillers like OxyContin and Vicodin.
