If, instead, it is functionally relevant, its repetitive nature will tend to be preserved by purifying selection [ 29, 30].
The conservation of this patch suggests it is functionally important, and its location in the M domain suggests that this function may involve positioning the stem of the protein on the ribosome.
This constraint biologically corresponds to the fact that a biological function can behave stochastically only when it is functionally active.
For Vaco411, we have previously reported that its mutation spectrum is inconsistent with an MMR defect and that it is functionally MMR competent when directly challenged with mispaired DNA substrates (Eshleman et al, 1998b).
Although the DMN is anatomically and functionally distinct from networks involved in sensory functions, comparative studies in animal and human studies have shown that it is functionally correlated with all other resting state networks [14].
Recently, it has been reported that the functional leptin receptor OB-Rb is expressed in endothelial cells and it is functionally competent [ 20].
It is functionally coupled with COX-2 in marked preference to COX-1.
Loss of the cell's capacity to synthesize protein is the ultimate proof that it is functionally dead.
(Technically, Verizon and Sprint, which operate a different kind of network than A.T. & T. and T-Mobile, use a Mobile Equipment Identifier (M.E.I.D ., though it is functionally equivalent).
If traditional male chivalry involves loud displays of care such as ostentatious door-opening, the entire point of female chivalry is that it is functionally invisible.
The MAC-10 has an effective range of only about 25 yards, but since most criminal conversations have a nasty sort of intimacy, it is functionally as well as aesthetically well suited to the job of intimidation.
