Sentence examples for it is extremely challenging from inspiring English sources

However, it is extremely challenging to reconstruct human kidney because of its complicated anatomical structure and no regenerating zone of renal tissue to form new nephrons [ 6].

"It is extremely challenging to get to the Olympic Park venues by bike.

However, it is extremely challenging to create such a vision system with precise localization, as well as motion control.

Controlling the order and spatial distribution of self-assembly in multicomponent supramolecular systems could underpin exciting new functional materials, but it is extremely challenging.

Furthermore, current patient-derived models for researching glioblastoma do not fully recapitulate the cellular diversity of tumor cells that are present in the tumor, so it is extremely challenging to classify those cells in order to match them with the drug therapies that work.

"The cuttlefish uses an ingenious approach to materials composition and structure, one that we have never employed in our engineered displays," said coauthor Evelyn Hu, Tarr-Coyne Professor of Applied Physics and of Electrical Engineering at SEAS. "It is extremely challenging for us to replicate the mechanisms that the cuttlefish uses.

"It was extremely challenging for the people concerned," he observes.

Chief executive Adam Wilkinson called it was "extremely challenging".

He added it was "extremely challenging" to secure funding for vehicle barriers in Windsor until the Westminster Bridge attack in March 2017.

It's extremely challenging to get long-term high volume offtake agreements to support the construction of these facilities.

It's extremely challenging for kids (10 and up) and adults, and quite fun.