Among many others, PML has also been established to mediate its tumor suppressive role by mitigating the inactivation of active AKT (pAKT) inside the nucleus by assembling a dephosphorylating platform for nuclear pAKT.
The Indian Act, various treaties and case laws were established to mediate relations between Europeans and native peoples.
BicD is established to play a critical role in mediating dynein function loss of BicD results in improperly localized nuclei, mRNA particles, and a dispersed Golgi apparatus however exactly what BicD's role is remains unknown.
ApoE has been well established to mediate the cellular uptake of lipoproteins by binding to the low-density lipoprotein receptor and the low-density lipoprotein receptor-related protein (LRP) (Lund et al, 1989; Yamada et al, 1992).
It is established that these serum proteins mediate cell adhesion by binding to transmembrane integrin receptors on the cells.
It is established that dynamic mechanical allodynia is mediated by peripheral low-threshold, large myelinated Aβ-fibers [7] [9].
It is established that increased levels of intracellular ROS may mediate changes in mitochondrial abundance and mtDNA copy number which occur during the ageing process [60].
It is established that voltage-dependent K+ channels (Kv) mediate repolarisation of β- cell action potential and thereby abrogate insulin secretion.
The mechanism of the vasodilator action of H2S has been established to be primarily mediated by KATP channels, which can be potentiated by NO.
Progressive latent TB in HIV/AIDS patients is similar to progressive primary TB except that Mtb infection, in this case, is established before HIV-mediated immunosuppression.
In addition, it has been established that hydrophobic patches mediate many high-affinity protein-protein interactions (Pechmann et al., 2009 ; Sivakolundu et al., 2008 ).
