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This is especially useful during the post-detection fine mapping phase to highlight primarily associated variants in diseases common in this population when it is essential to exclude secondary hitchhiking effects.
In evaluating cases of thrombocythemia, it is essential to exclude both reactive processes and other chronic myeloid disorders prior to making the diagnosis of essential thrombocythemia.
As even slight contaminations by nasal NO greatly affect the level of exhaled NO, it is essential to exclude the upper airways when determining FENO.
Since a number of mitochondrion-toxic drugs are used to treat mood and psychotic disorders and may worsen the underlying metabolic defect, it is essential to exclude a mitochondrial metabolic defect before applying these agents.
19 21 When age groups are built it is essential to exclude the dividing biographical date from the analysed time frame to account for the dip-peak effect, which Roger described as "to be expected from the sampling procedure used and not related to 'birthday stress' factors".
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It has been suggested that the asymmetric distribution of Ed is essential to exclude the polarity protein Bazooka (Baz) away from the LE (Laplante and Nilson, 2011; Pickering et al., 2013).
Bronchoscopy is essential to exclude double-lumen tube displacement and to re-position it if necessary.
Adequate histological sampling is essential to exclude a GB.
Histology is essential to exclude vasculitis and malignancy, and special stains and tissue cultures may also be used to rule out infection.
Biopsy of all pancreatic masses is essential, to exclude potentially curable conditions such as PPL, and can be performed without laparotomy.
Histological examination before p53 testing is essential to exclude cases where the p53 result may reflect only the status of the normal cells in the biopsy.
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