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However, it is difficult to true these diamond wheels efficiently, because of the remarkable resistance property and the geometrical limitation of small wheel profile.
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Even in association studies with Arabidopsis inbred lines it is difficult to distinguish true associations from false ones because of confounding by complex genetics and population structure [26].
Second, it is difficult to distinguish true infection from colonization.
Even then, it is difficult to make true or false statements.
Though it is difficult to assess true affordability, treatments costing one days' wage or less were considered affordable [ 7].
The median survival of mCRPC has shifted from 20 months to longer, although it is difficult to estimate true life expectancy.
In other words, it is difficult to distinguish true genetic associations and gene regulatory differences from spurious patterns in the GWAS and gene expression profiling studies, respectively.
However, it is increasingly recognized that for some complex endpoints, it is difficult to define "true" results, especially when the goal is the prediction of adverse outcomes in humans.
In theory, all children whose parents responded "yes" or "don't know" to any of the three questions on the CDC Lead Risk Assessment Questionnaire (CDC 1997) should have been screened for lead, but it is difficult to ascertain true practice at the time.
Generally, it is difficult to estimate true regulations in a highly correlated data set, since the Markov equivalence classes of a directed network cannot be identified uniquely (Uhler et al. 2013).
However, analysts say while there is evidence the programme is advancing, it is difficult to assess its true extent.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com