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It is difficult to correctly assign their values based on related haplotypes, and they therefore tend to receive the allele frequency from the reference panel.
However, in our opinion this approach is more appropriate for stable patients managed into ambulatory setting, since it is difficult to correctly classify CKD in acute patients, especially when GFR is higher than 60 mL/min/1.73 m.
In particular, for genes with many paralogs, it is difficult to correctly assign orthology relations using automated prediction methods that rely only on gene sequence information (Koonin 2005,Notebaart et al. 2005).
Both methods have advantages and disadvantages and it is difficult to correctly reproduce real flows with inherent uncertainties.
It is difficult to correctly assess the depth of tumor invasion from resected materials by conventional endoscopic procedures in lesions larger than 15 mm.
Finally, it is difficult to correctly interpret results obtained in this complex chaining assay because the courting as well as the courted males share the same sensory defects, which probably not only affects the behavior of the courters but also that of the courtees.
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DW-MRI may also have a role in the identification of residual tumour (Fig. 14a d) after neoadjuvant chemotherapy, when it can be difficult to correctly evaluate tumour size with conventional breast MRI.
We report a rare case of a rupture of an aneurysm of a coronary-pulmonary fistula that was difficult to correctly diagnose before performing emergency surgery.
In addition, ABF-2 contains four intramolecular disulfide bridges, and thus it is difficult to produce correctly folded and active ABF-2.
One reason for not asking about the precise location of POST may be that it is difficult to explain correctly.
Genes in the TCR complex possess highly repetitive sequences, so that it is difficult to generate correctly reconstructed loci from shotgun sequencing with low redundancy or short-read next-generation sequencing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com