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Also, it is difficult to administer intravenously because of its low solubility in aqueous media.
The other commercially available antiviral medicine in this class is Relenza, made by GlaxoSmithKline, but it is difficult to administer.
Usually in the elderly it is difficult to administer the same chemotherapy administered to younger patients because elderly patients tolerate chemotherapy poorly.
"The problem with a targeted system is it is difficult to administer and doesn't have the same buy-in as a scheme that offers support as widely as possible".
However, it is difficult to administer the lipids deep into the interface in healthy skin using conventional formulations such as ointments and creams.
The majority of patients received 18 Gy in one fraction, and as other authors pointed, because of the high radiation dose already given in the initial treatment with EBRT, it is difficult to administer a high dose [ 17].
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It's difficult to administer in practice (there are lots of opportunities for avoidance, and which innovation policies count? Research grants? Procurement?).
There are other problems too: it's difficult to administer in combination with other drugs and the infant formulation requires a cold chain.
Due to lack of funding, it was difficult to administer questionnaires to a very large sample.
It was difficult to administer a questionnaire immediately after the earthquake, which is why we obtained data about clinical characteristics and activities from both questionnaires and medical records.
Warfarin is difficult to administer properly, requiring frequent monitoring of the active levels in the blood to avoid thinning it too much or too little.
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