When it is cleaved by active cleaved caspase-3, PARP loses its DNA repair function and signals the cell to move into apoptosis (Cohen, 1997).
Once it is cleaved, its subunits become excitable at 649 nm and emit a red signal that can be measured as an indicator of activity of MMP 2, 3, 7, 9, 12 and 13.
There, it is cleaved into its mature subunits, sucrase and isomaltase, by pancreatic proteases.
It is cleaved from its inactive precursor big-ET1 by endothelin-converting enzymes 1 (ECE1) and 2 (ECE2) (Yanagisawa et al., 2000).
After the dissociation of GRP78, ATF6 translocates to the Golgi apparatus where it is cleaved into its active form by site-1 and site-2 protease.
PINK1 is imported into the mitochondria in a ΔΨm dependent manner where it is cleaved by PARL in the IMM, restricting its expression (Fig. 4) [108–110].
It is cleaved by γ-secretase activity, which allows its signal transduction component to translocate to the nucleus and activate transcription.
CK-18 is the major intermediate filament protein in the liver; during activation of cell death pathways, it is cleaved by the caspases (mainly caspase-3) and its fragments are released into the circulation (11– 11).
PS1Aa1 has a typical architecture characteristic of the three-domain insecticidal Cry toxins, though it is cleaved into two polypeptides.
Chinese society is prospering, even as it is cleaved by inequality and struggling with human rights abuses, corruption and severe pollution.
It is unclear what factors induce Gli3 in the forebrain10, but it is cleaved into a Hh-repressor form (Gli3R) where Hh activity is low21.
