However, until now this effect has been challenging to observe because, first, it is experimentally difficult to apply a sufficiently large thermal bias at the nanoscale and, second, it is difficult to distinguish thermal bias effects from purely temperature-dependent effects due to overall heating of a device.
It seems possible that class membership, particularly for potentially contentious decisions, might depend more strongly on attitudes and beliefs, cultural differences, and/or individual tastes, all of which are challenging to observe or measure, than on sociodemographic characteristics.
This, in turn, can help to identify aspects to further analyze in empirical studies, being in particular useful for phenomena that are challenging to observe in real animals (or difficult to reproduce in controlled experimental conditions).
In live cells it is challenging to directly observe the partitioning of proteins, because the constricting septum of E. coli becomes smaller than the optical resolution limit during the proposed process.
Postcopulatory processes are indeed challenging to observe and to quantify, mainly because they often occur inside the female reproductive tract.
Furthermore, over a 9-month period it will be a challenge to observe significant between group changes when comparing the (S partner intervention with control schools.
As we note that significant advances in machine learning and artificial intelligence open new possibilities and challenges for higher education, it is important to observe that education is eminently a human-centric endeavor, not a technology centric solution.
However, relating the distinctive electrophysiological profile between VD and MD patients to what is clinically observed is challenging.
Observing interference effects is challenging because of two other difficulties.
