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It is also not apparent why some cancers are sensitive for drugs such as Bortezomib, Vorinostat and Geldanamycin that inhibit the proteasome, histone deacetylases and HSP90 respectively, since these cellular targets are not directly implicated in tumorigenesis.
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What is also not apparent to audiences is that despite the Warner logo, the film was fully financed by a new company called Franchise Pictures, whose chairman, Elie Samaha, has burst on the Hollywood scene in the last year and carved out deals with some of the biggest names in Hollywood, including Mr. Willis, John Travolta and Sylvester Stallone.
The degree to which different interventions contribute to goal attainment and caregiver burden is also not apparent.
At first glance, it is also not readily apparent merely from the CIC and doctrine of marks and traces why a substance cannot be constructed from two substances or be divided into two new substances.
It is also not always apparent which letters are capitalized owing to the Gothic or blackletter typeface which was used to print the Bible.
It is also not immediately apparent why the changes in global patterns of gene expression induced by the displacement of endogenous miRNAs should be functionally coordinated.
It must be noted however that in HSC SOCS3 upregulation was also not apparent at later time points following IL-27 stimulation (data not shown).
The changes in antihypertensive and statin treatments were also not apparent before or after 4 years of sitagliptin therapy.
Growth differences were also not apparent when immortalized murine embryonic fibroblasts (MEFs) or macrophages from SerpinB2+/+ and SerpinB2−/− mice were tested (Figs. S9 and S10).
The correlation between sTfR and parity was also not apparent from our data, this is, when parity was handled as the raw, categorical variable (p = 0.2), yet the correlation became highly significant when parity was handled as a binary variable (0.005).
Other examples, such as the asymmetric localisation of SEP3 in the epidermis of both sepals and petals and its possible role in the adaxial/abaxial patterning of these organs, the presence of FUL protein in the replum of developing pistils, or the presence of AG in the nucellus of the developing ovule during the down-regulation of WUS were also not apparent from the reported mRNA patterns.
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