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It not only fulfills all the criteria of a transmembrane protein localized to INM but it is also functional as an ion channel conducting potassium.
The VRK1 downregulation is also independent of a proteasome mediated pathway; this mechanism is insensitive to proteasome inhibitors, and hdm2/mdm2 is not implicated since it is also functional in mdm2 deficient cells [12].
As we show in this work, it is also functional in mouse aorta endothelial cells.
In this region, the Initiator motif (Inr: YY AN(T/A YY, TSS is underlined) is known in some mammalian promoters [ 1], and it is also functional in plants [ 42].
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"Visually, it's a clean, modern setup, and it's also functional.
Though it may be a variant of miR847*, it is possible that the small RNA is also functional because it has an 8 nt overhang instead of 2 nt, which the DCL product generally has (Fig. 3).
Although it was shown that MTE is also functional (in vitro) in human promoters [ 2], the preliminary statistical analysis of two human promoter databases (Eukaryotic Promoter Database [ 25] and Database of Transcriptional Start Sites [ 26]) using any of three considered above consensuses did not show overrepresentation of MTE at expected functional positions in human promoters.
As explained in Qualitex, supra, and Inwood, supra, a feature is also functional when it is essential to the use or purpose of the device or when it affects the cost or quality of the device.
It is also a functional million-gallon water tower, built by the Chicago Bridge & Iron Company.
It is also a functional polymer with potential to provide environmental friendly biomaterials [ 8].
It is also relevant for functional analysis as ultraparalogs likely share a similar function and are often involved in functional redundancy and/or neofunctionnalization.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com