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Functionally, an individual miRNA is important as a transcription factor because it is able to regulate the expression of its multiple target genes (Chen and Rajewsky, 2007).
However, whether it is able to regulate autophagy remains largely unknown.
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These data suggest that the alveolar epithelium actually is dysfunctional after alcohol exposure, even though it seems normal and is able to regulate the normal air liquid interface by enhancing sodium channels at the apical surface.
Taken together, these data make it clear that CKI-ε is able to regulate TGF-β-induced Bim expression by affecting FoxO3 phosphorylation status and support the model in which TGF-β stimulates apoptosis by trigger the CKI-FoxO/Smad-Bim engine.
Nevertheless, it is possible that PTK6 is able to regulate proliferation via protein-protein interactions independently of kinase activity.
When focusing on the hallmarks of cancer [ 43], it is evident that NFκB is able to regulate nearly every aspect of tumor biology, including the promotion of cell survival, the induction of cell proliferation, the promotion of metastasis and the stimulation of angiogenesis.
More recently, it has been shown that insulin is able to regulate different processes within the placenta at different gestational stages, using a global microarray analysis of primary trophoblasts [10].
Indeed, it has been demonstrated that SNX23 is able to regulate the microtubule-dependent transport of FGFR-containing vesicles or early endosomes.
It remains unclear exactly how NRP1 is able to regulate p130Cas phosphorylation, and investigation of the molecular mechanisms involved warrants further experimental work.
miR-17-92 is an oncogenic miRNA cluster implicated in the development of several cancers; however, it remains unknown whether the miR-17-92 miR-17-92 miR-17-92regulate clusteriscablenogenesis.
Thus, it is certainly conceivable that HPV E6 is able to regulate the expression of many cellular microRNAs through p53, which acts as a checkpoint to maintain cell homeostasis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com