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Obviously, if the car won't start or catches fire, then it is a substantial problem.
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"It's a substantial problem," Botstein recognized.
Corneal endothelial dysfunction is a substantial problem in FECD, and it is accompanied by visual disturbance which provides a major indication for corneal transplantation surgery [138].
Fraud is a substantial problem, and the attitude toward it has changed little over the years, other editors say.
From a global perspective, right now we are building up a huge problem in the west with our net debt and this is a substantial problem for development.
Because of the high cost of so many films, many studios have been eager to thwart film piracy, which is a substantial problem for American films in Asia.
Low patient adherence is a substantial problem in therapy.
I told him that from what I'm hearing, this is a substantial problem for homeless women ― not a one-time event.
In order to preserve the Kansas law, he will have to show that noncitizen voter registration is a substantial problem and that nothing short of the state's proof-of-citizenship law can stop it.
This is a substantial problem for spotted-tailed quolls, as they kill relatively large possums and cannot finish their meal before devils arrive.
Bullying in school is a substantial problem for Greek youth.
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