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It is a substantial challenge to fairly represent this uncertainty in a Monte Carlo analysis.
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"It's a substantial challenge for Ratner to finish this project within the time frame he's proposing.
There is a substantial challenge facing views such as Reid's.
This is a substantial challenge for those who design and provide information.
Extracting accurate Bragg peak intensities from XFEL diffraction data is a substantial challenge.
The fact that Cox doesn't is hardly a substantial challenge to that statement.
However, it is a substantial increase and it is a challenge for companies like us".
It is conceivable that the interplay of those disorders could be a substantial challenge for training.
For such complex and contentious stuff that's a substantial challenge.
The reassembly of these reads into contiguous fragments (contigs) is a substantial computational challenge for metagenomics.
Nevertheless, there are substantial challenges to achieving the family planning benchmark in many countries.
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