Sentence examples for it is a considerable challenge from inspiring English sources
Currently, computational investigation of lncRNA functions is still at its early development stage, since it is a considerable challenge due to the characteristics of lncRNAs, e.g., many lncRNA gene sequences are not conserved and do not contain conserved sequence motifs [ 7], which makes it difficult to infer potential functions of lncRNAs based on their sequences alone.
It is a considerable challenge to fabricate this kind of fibrous scaffold.
Due to the adaption, dynamic and multi-objective characteristics of complex water resources system, it is a considerable challenge to manage water resources in an efficient, equitable and sustainable way.
It is a considerable challenge, because of the myriad of fields from which data can be recorded, and the variety of end-users.
It is a considerable challenge to integrate the numerous targets and effectors, and to integrate this knowledge into an accurate understanding of the mechanisms by which effector proteins cause diseases.
However, because NMDA-Rs are expressed in most cell types in the brain (Conti et al., 1997; Verkhratsky and Kirchhoff, 2007), it is a considerable challenge to selectively assess the importance of NMDA-R mediated synaptic plasticity in specific cell types.
The regulator was targeting several "household brand names", Mr Pollack said, but it was a considerable challenge to trace many of the companies responsible so action could be taken - with the identity of 75% of callers not traceable from their phone numbers.
As a consequence, it was a considerable challenge to mount this pilot study, given the prevailing assumption that exercise intervention is not appropriate for women undergoing chemotherapy for ovarian cancer.
Returning to comics, the author Warren Ellis is an exceptional talent at contextualising plot within the opening two or three pages, often merely visually, without signposting it, which is a considerable challenge in video-game world building.
For the telecommunications company, providing a mobile office in the Formula One environment is a considerable challenge, although it is one that helps them prove and develop their systems.
Understanding the pathological role of mHtt is a considerable challenge given its ubiquitous expression in the body.
