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Currently, computational investigation of lncRNA functions is still at its early development stage, since it is a considerable challenge due to the characteristics of lncRNAs, e.g., many lncRNA gene sequences are not conserved and do not contain conserved sequence motifs [ 7], which makes it difficult to infer potential functions of lncRNAs based on their sequences alone.
It is a considerable piece of work.
It is a considerable one.
It is a considerable affair.
It is a considerable worry.
It is a considerable puzzle.
He added: "It is a considerable achievement".
It is a considerable amount of carbon," he said.
And it is a considerable piece of barrier-breaking".
At about $15, it is a considerable bargain.
It is a considerable improvement on the original.
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