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Extensive research to inform intervention development may seem inappropriate given the urgency of the epidemic, but without it interventions are less likely to utilize endogenous motivations in culturally appropriate ways.
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It will not be possible for us to determine which component(s) of the TAKE-IT intervention are most powerful in promoting adherence.
Furthermore, the TAKE-IT intervention is clinic-based, and integrated with usual clinical care, making it feasible for application in practice.
An important feature of the TAKE-IT intervention is that it is administered repeatedly at regular intervals – an intervention approach [ 46, 47] demonstrated to offer better sustained treatment effects than interventions delivered in single session or concentrated formats [ 48, 49].
Typical dropout rates in IT based interventions are approximately 30% [ 16].
It is unknown which interventions are effective and how long the follow-up period should be.
It is unclear which interventions are required to change the perspectives of the general public.
However, it is unknown whether these interventions are best delivered pre- or postoperatively.
"Right now, it is unknown whether single interventions are as cost effective as combinations of these interventions.
In clinical trials it is imperative that the interventions are adequately defined and described [86].
It is likely that other interventions are more cost-effective.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com