Although the tumour physiopathology implies a defect in activation-induced cell death, the treatment is designed to kill the transformed cells.
Factors requiring consideration include, the size of the joint, the cartilage thickness, the depth and critical size of the defect (critical size implies a defect which will not heal spontaneously without any intervention), the age of skeletal maturity (better results in young patients regardless of treatment type), load distribution of the stifle, affordability and ease of animal handling.
This finding implies a defect in adaptation to hypoxia in patients with COPD due to poor activation of HIF-1α.
However, these axons failed to project to the contralateral side and alternatively stayed on the electroporated side, implying a defect in axon guidance.
Therefore, a decreased insulin signaling should imply a defect in insulin stimulation of the GLUT-4 translocation.
In addition, TBF-treated cells were misshapen compared to untreated cells, implying a defect in membrane structure and function.
Therefore, the nucleolar hypertrophy in yao embryo sac, zygote and preglobular embryos may imply a defect in ribosome biogenesis.
A second form of CSR abnormality reported in 16 patients was associated with radiosensitivity implying a defect in dsDNA repair mechanisms (Peron et al, 2007).
In addition, NeuroD exhibits a similar expression pattern in the Dsp mutant when compared with the Bcl11b mutant including a 1.4-fold increase of NeuroD-positive cells implying a defect in neuronal differentiation.
Although the percentage of reticulated (newly formed) platelets was unchanged in BCL-2tg compared with WT mice, their absolute number was significantly reduced, implying a defect in platelet production from megakaryocytes.
