The analysis also implicated energy metabolism and caloric intake control as potential influences on alcohol consumption by the recombinant inbred rats.
The present finding of a peak in energy metabolism-related gene expression in the adolescent brain is of particular interest in light of an increasing body of evidence from our laboratory [ 77- 80] and others [ 81- 84] implicating energy metabolism deficits in schizophrenia and, to a lesser extent, bipolar disorder [ 82, 85].
Three such XI-mutations were present in Xp (Part II of Additional file 7) with high frequency (>80%), implicating energy conversion (COG C, electron transport complex I (Teth5140079) and lactate dehydrogenase (Ldh, Teth5140216)) and ion transport process (COG P, TrkH family potassium uptake protein (Teth5140140)).
crtc3 is a transcription factor downstream of cAMP and CREB signaling and, like irs2, it has been implicated in energy metabolism.
Both have uncoupling activity in vitro and may mediate the increased energy expenditure implicated in energy balance.
This hallmark feature of CaCCs implicates hydration energy as a factor in anionic selectivity, a feature shared with cystic fibrosis transmembrane conductance regulator (CFTR) channels (Qu and Hartzell, 2000).
Thus, a large fraction of the transcriptional activity in the heart relates to generation of energy with almost one third of the transcripts encoding proteins implicated in energy metabolism.
Since an increase in the apparent Kd was also observed in several allosteric NAEs [16], [18], [27], [28], it might implicate that an extra free energy is usually required to drive the conformational transition in both allosteric and ASAP systems.
Osteocalcin, a protein synthesized by osteoblasts, and vitamin D status have independently been implicated in energy metabolism and glucose regulation.
Proopiomelanocortin (POMC) neurons are critical sensors of nutrient availability implicated in energy balance and glucose metabolism control.
The influence of carbohydrate source on growth, exopolysaccharide (EPS) production and on the activity of the enzymes implicated in energy generation and UDP-glucose synthesis in Pediococcus parvulus 2.6 was evaluated.
