The phrase 'it imperative to understand' is correct and usable in written English. You can use it when you want to emphasize that something is extremely important, or needs to be taken seriously. For example: "It is imperative to understand the risks involved with this investment before committing to it."
In this context, the identification of Prod1 as an important molecular component in urodele limb regeneration renders it imperative to understand its molecular phylogeny, and in particular to establish whether there are functional orthologs for Prod1 within other phylogenetic groups.
This makes it imperative to understand their mechanisms of action and consequently design effective RNA-based strategies in the diagnosis, prognosis, and therapy of cancer.
This makes it imperative to understand the effect of dams on ecosystems and people and apply best practice to limit the damage done to the river.
"We consider it imperative to understand what it is about high-volume institutions that leads to their providing higher quality of care, so that we can ultimately improve the quality of care at all institutions".
A broad range of molecular phenotypes are possible depending on the type and severity of the mutation, making it imperative to understand the consequences of splicing mutations.
Severe ecological and economic impacts caused by some invasive species make it imperative to understand the attributes that permit them to spread.
To understand the subject of terrorism, it is imperative to understand what it is about.
In order to appreciate the role of privacy data preservation, it is imperative to understand how it fits into the overall architecture of a privacy protected video surveillance system.
Because of its ubiquitous nature, it is imperative to understand the mechanisms underlying formaldehyde-induced toxicity and carcinogenicity.
Thus, if brain aging causes low-level chronic inflammation it is imperative to understand the reasons for it.
If NB is a tumour partially derived from a failure to undergo the appropriate developmental programme of differentiation, it becomes imperative to understand what that developmental programme is, and where it becomes arrested or disrupted in NB.
Ludwig does not simply clarify my doubts with English writing, it enlightens my writing with new possibilities
Simone Ivan Conte
Software Engineer at Adobe, UK