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Using chemical cross-linkers, any antigen can be placed directionally onto the VLP surface, rendering it highly immunogenic.
Slight changes in LDL make it highly immunogenic.
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In spite of its highly immunogenic properties, Mycobacterium tuberculosis (Mtb) establishes persistent infection in otherwise healthy individuals, making it one of the most widespread and deadly human pathogens.
Although it is highly immunogenic in human pathology, it is not a major constituent of peripheral nerve in humans.
This protein is well recognized in immunoassays by serum from human convalescent meningococcal disease and it is highly immunogenic in animals.
In other words, RTB is poor in elicit antiricin neutralizing antibodies although it is highly immunogenic in eliciting nonneutralizing antiricin antibodies [ 24].
Previous studies have shown that when M2e is linked to hepatitis B virus core (HBc) particles, it becomes highly immunogenic, eliciting protective antibody response in mice (25 ).
In a previous study, a recombinant genotype 1 HEV peptide (HEV 239; Hecolin; Xiamen Innovax Biotech, Xiamen, China) was found to occur in solution as large aggregates rather than true VLPs [ 32], but it was highly immunogenic.
KLH, a large copper-containing protein of multiple subunits of 350Kd has become popular as a carrier protein because it is highly immunogenic and expressed only in arthropods and molluscs.
Immune strategies will be important in designing effective treatment of melanoma because it is a highly immunogenic tumor.
The ompA gene is present in all Salmonella enterica serovars and it encodes an abundant, highly immunogenic outer membrane protein.
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