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It has made a substantial difference during these last 21 years that Anthony Kennedy got the seat intended for Robert Bork.
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So far, nothing has made a substantial difference in Casey's behavior.
I think we had a moment some years ago where it might have made a substantial difference".
Because of an editing error, a misplaced quote of Wendy Sherman's made it unclear what Hillary Clinton's undersecretary of state for political affairs said might have made a "substantial difference" in Syria.
Though the higher prices can be a moderate nuisance to real estate businesses or home buyers, they have made a substantial difference to the county budget.
Program design appears to have made a substantial difference in both static and dynamic benefit incidence.
Nothing seems to have made a substantial difference yet.
These contributions have made a substantial difference in the fight against HIV/AIDS.
Given the methods used, using the median and interquartile range to describe transfer durations, this is not likely to have made a substantial difference to the results.
It has made a difference.
All authors have made a substantial contribution to the manuscript.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com