DOI: http://dx.doi.org/10.7554/eLife.07295.036 Still, it has been shown before, as the reviewers point out, that the detection of differentially expressed genes can have a bias on genes with longer exons or more general on genes with higher read counts.
Phosphorylation of this Vav1 site is a good reflection of its activation status, since it has been shown before that this posttranslational modification induces a conformational change in the Vav1 molecule that stimulates its GDP/GTP exchange activity towards Rho/Rac proteins [27] [29].
However, it has been shown before that the degradation of HA by WRF enzymes could be associated with mineralization of HA molecules (Paper et al. 1998; Steffen et al. 2000).
It has been shown before that SLNs can pass the BBB efficiently [23].
As it has been shown before [11], ANNs are able to estimate physical magnitudes in highly undetermined systems.
It has been shown before that the efficiency of such devices can be increased significantly upon incorporation of an imidazolium-substituted polythiophene interlayer.
It has been shown before that patients with ICA occlusion and a compromised flow state of the brain may improve spontaneously over time [25].
It has been shown before that different designs of orchard sprayers result in different airflow profiles, but it is still unclear whether these differences strongly affect on-target spray distribution, and what is the role of tree architecture.
It has been shown before that entries in miRBase are questionable and the chance of incorporating a large share of low-quality hairpins increases with the number of hairpins available when using MCCV.
It has been shown before that "lesser mobilization of older parents [with younger children] is linked to worsening living conditions, themselves due to unemployment or illness, a less favourable local context due to suburban decay.
It has been shown before that the dura mater contains a rich supply of sensory substance P and CGRP fibers, and of sympathetic noradrenaline and neuropeptide Y, but only a minor amount of parasympathetic VIP and PACAP containing fibers [46].
