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Combining these observations with previously reported mutagenesis studies on different S-helix-containing proteins we suggest that it functions as a switch that prevents constitutive activation of linked downstream signaling domains.
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A computational model of the dynamics of this core network has revealed that it functions as a bistable switch, which in the on state, corresponds to all these TFs being expressed and the downstream differentiation target genes being shut off [11].
It functions as a master switch during differentiation by regulating gene expression in pluripotent cells, or in cells that can develop pluripotent potential (Ovitt and Scholer, 1998; Pesce and Scholer, 2001).
This modification functions as a switch to open the chromatin configuration to enhance BCRP transcription.
These observations suggest that the conserved RT signature of the linker forms a distinctive structural feature that functions as a switch within the CC.
Depending on how it is loaded, a hair bundle can function as a switch, active oscillator, quiescent resonator, or low-pass filter.
Furthermore, this reliable and effective MEA based bioelectronic tongue functioned as a switch for stimulation On and Off.
Since Kv channel activity is largely responsible for setting the resting membrane potential in these cells, Kv activity may function as a switch between the decision to self-renew or to differentiate44.
W65 in the aromatic cage may function as a "switch".
We propose that CtrIncA could function as a switch to regulate the maturation of the inclusion.
Analysis of the bifurcation structure also reveals novel, programmable multi-functionality; in addition to functioning as a frequency multiplier, the network is able to function as a switch or an oscillator, depending on the temporal nature of the input.
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