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The case, Medtronic Inc. v. Boston Scientific Corp., No. 12-1128, concerns devices made by Medtronic that deliver electrical jolts to the heart when it fails to pump normally.
"It opened a whole new era for understanding how the heart functions as a pump and what goes wrong when it fails to pump efficiently," said Dr. Heinrich Taegtmeyer, a professor of medicine at the University of Texas Health Science Center in Houston.
The heart becomes so weakened by age or disease that it fails to pump enough blood to drain out fluid.
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MRP6 can transport GSH conjugates such as LTC4 and n-ethylmaleimide-glutathione; however, it failed to pump out any glucuronate conjugates such as E217βG [160], [160].
It is the proper function of a heart to pump blood (say) even if that heart fails to pump blood or even if it does something else, even something that happens to be useful to the organism.
This may imply that the molecular determinants of a proton pump are more demanding than those of a chloride pump, and indeed, an NpHR mutated to contain 10 key BR-like amino acids still fails to pump protons (Supporting Information Figure 3), consistent with its lack of a strongly hydrogen-bonded water.
The LVAD is used to restore blood flow when the left ventricle fails to pump enough blood to sustain life.
In a sense, heart failure is simple: the heart fails to pump blood forward, so fluid backs up.
Hospitals admit 1.1 million adults each year for congestive heart failure, a condition in which pressure builds up in the circulatory system and the heart fails to pump blood adequately to the rest of the body.
Coleman has congestive heart failure, an inexorable disease in which the heart fails to pump hard enough.
During these sudden episodes an already overtaxed heart fails to pump robustly enough, causing the lung tissues to fill up with blood.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com