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In view of recent data from our laboratory showing that ACT induces increases in [Ca2+]i in target cells [13], we designed this research to explore the downstream effects derived from this toxin-induced calcium influx.
Though the present study did not explore the downstream effects mediated by STAT3, previous studies show that STAT3 phosphorylation targets both nucleus and mitochondria [ 14].
To further explore the downstream effects of inhibiting the MAPK pathway by DHAvD in UVB-irradiated HDFs, the DNA-binding activity of NF-κB and AP-1 was examined by EMSA.
As in other model organisms, microarray data have been used in zebrafish to generate transcriptome profiles during embryonic development [ 24] as well as to explore the downstream effects of mutant alleles [ 23, 25, 26].
It explores the effects of drugs and drug dealing on school kids, families and communities.
It explores the effects of import tariff removal for meat and livestock entering China.
It explores the effects of wartime destruction through photography and ceramic models.
It explores the after-effects of catastrophe on the individuals who have survived.
However, it is the downstream effects and integration of signalling that are important.
In the context of SMAD6, our results clearly demonstrate statistically significant differences between some of the mutant and wt SMAD6 proteins with respect to inhibitory activity in the in vitro assays, but the quantitative effects of different levels of mutant constructs remain to be explored, as do the downstream effects of BMP ligand treatments in the mutant cells in vivo.
It explored the polarizing effect of the shooting.
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CEO of Professional Science Editing for Scientists @ prosciediting.com