Indeed, the mice treated with gemcitabine or its combination with isoCA-4 and SQCOOH/isoCA-4 NAs exhibited significant weight loss (12 15%), below the usual value of the maximal tolerable dose (MTD) (i.e., 10%), showing the toxicity of these treatments.
Pure graphite does not exhibit any weight loss in the temperature range of 0 900 °C; however, GRO exhibited significant weight loss in several steps, due to the presence of various oxygen-containing functional groups [61].
Beginning at approximately 10 weeks of age, R6/2 mice exhibited significant weight loss and by 14 weeks the vehicle-treated R6/2 mice were approximately half the size of wild-type littermates.
During the feeding trial, both sexes lost weight when fed at the LFI, however, in the HFI group, only males exhibited significant weight gain (Table 4).
IAV-infected Serpine1 −/− mice exhibited significant weight loss and succumbed to infection on average 1 day earlier than B6 parental mice.
Exposure to 25, 50, and 75 mg/kg/day BaP for 28 days caused no overt signs of toxicity in any of the animals on necropsy, and no animals exhibited significant weight loss compared with control (data not shown).
When mice received one dose of mAb prior to viral challenge (three-dose regime), no significant weight loss, which is a measure of clinical illness, was observed following challenge in the mice that received SUDV-specific antibodies, whereas the Z.6D8-treated control animals exhibited significant weight loss (maximal loss of 25%).
Over the 12-wk feeding trial, C57BL/6 mice fed the high-fat diet consistently gained weight, while the other treatment groups failed to exhibit significant weight gain (Fig. 1a).
Animals C, D and E did not exhibit significant weight loss or other clinical signs or symptoms of disease (Table 1).
While palcA is inducible, it exhibits significant basal expression.
The AA rats exhibited significant body weight gain (P < 0.05) in HP-R3 group; while the HP-R1 and HP-R2 also increased the body weight of AA rats, there was no significant difference.
