Sentence examples similar to it entailed significant commitment from inspiring English sources

Cell-based assays are essential for validating the pharmacological activity of drug candidates; however, development for a large number of these candidates is often discontinued during subsequent animal testing or clinical trials, which entails significant commitments in terms of costs, time and energy.

While generally less risky because it was less visible, this type of resistance still entailed significant risks if detected.

But they also entailed significant dangers.

Indeed, once the popularity of a cultural experience reaches a certain threshold, failure to consume it may entail significant social costs.

While the DSM system achieves those aims, it also entails significant difficulties.

The procedure sometimes yields improved long-term survival, yet it can entail significant morbidity during the initial recovery [ 1- 3].

It will not only drive decisions in a different direction, but it may also entail significant changes in organization structure.

It entails a commitment to recognise the intrinsic value and dignity of women's context.

It entails a commitment to recognise the intrinsic value and dignity of girls' and women's context.

Even with the tax deduction that companies receive for cash deals that often entail significant borrowing, companies find it cheaper to finance their purchase with equity.

It involves thinking beyond the obvious and necessarily entails significant creativity.