After neurotransmitter is released from the presynaptic terminal, it diffuses across the synaptic cleft and binds to receptor proteins on the postsynaptic membrane.
Substrate solution flows through the dialyser tube side from where it diffuses across the hollow fiber wall into the stagnant cell suspension and reacts irreversibly to form product. Products then back-diffuse to the tube side.
This molecular gradient was achieved by stamping the cysteamine on a gold substrate and letting it diffuse across the surface, followed by backfilling with ODT molecules.
When CO2 is assimilated by an aquatic alga, it diffuses across the plasma membrane from the environment to the intracellular CO2 pool, which is followed by carboxylation catalyzed by ribulose bisphosphate carboxylase/oxygenase (RubisCO).
When added to the HCO3− concentrate, it diffuses across the dialyser membrane to donate iron directly to transferrin.
NO is toxic to bacteria; it diffuses across cell membranes into the cytoplasm and reacts with iron centers and thiols causing so-called nitrosative stress [ 222].
Firstly, free EtNBS easily diffuses across cellular membranes and becomes trapped in lysosomes, while the construct is taken up only through a receptor-mediated process.
Nearly all stimuli that produce vasodilatation do it through nitric oxide (NO), a volatile gas, biologically active, present practically in all tissue and thanks to its low molecular weight and its lipophilic properties it diffuses easily across cell membranes.
It is highly lipophilic, so it diffuses quickly across the blood-brain barrier.[ 37] The pharmacokinetics of fentanyl makes it particularly suitable for the treatment of BTP.
Based on the above collective considerations and the current results, a hypothetical transport model for albumin might be delineated as follows: albumin reaches rapidly the Golgi from the ER, where it diffuses rapidly across the stack at a rate dependent on the number and transiency of the connections, accumulating in the low pH trans-Golgi compartments.
Moreover, high lipophilicity of [18F]TFAHA (LogP = 2.34) enables it to diffuse across the capillaries with intact BBB and rapidly equilibrate between blood and tissue compartments in the normal brain regions.
