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Local authorities also have no mandate to record the sexual orientation or gender identity of those accessing services, making it difficult to map demand or work on prevention.
Large inconsistencies in characterisation data, toxicological measurements and exposure scenarios make it difficult to map and compare the risk associated with NMs based on physicochemical data, concentration and exposure route.
The complex etiology of hypertension has made it difficult to map disease-related genes.
But these receptors also tend to cluster together in genomic regions with high LD, which was thought to make it difficult to map the genetic drivers of interindividual variations in sensory perception with the help of association studies.
Moreover, if RNA-Seq is conducted by a poly-A enriched approach, the internal bias against 5′ ends make it difficult to map out the exact start sites of a transcript.
One of the main issues standing in the way of uncovering the distribution of centromeric nucleosomes is the fact that most regional centromeres are localized to homogeneous tandemly repetitive regions of the genome, making it difficult to map individual nucleosomes.
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However, the composition of the peptide (22 lysine, 18 alanine, 7 threonine, 6 valine, 5 serine, 5 proline, 2 isoleucine, 1 glycine and 1 aspartic acid residue) and its size (6.7 kDa), made it very difficult to map the site of modification using conventional proteases or tandem mass spectrometry.
For species whose decline preceded the modern era and whose distribution is in the developing world, it is difficult to map suitable habitat across its former range.
It was difficult to map all clinics in the three areas; therefore it is possible that not all clinics were found.
It is difficult to map all this out conceptually.
However, for most areas it is difficult to map the distribution of contaminants in the soil or sediment, and spatial interpolation algorithms often must be employed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com