Acetylation of critical positively charged residues of ANT1 could affect the electrostatic properties and inhibit the initial capture or binding of ADP or could perturb its structure or dynamics, possibly changing the shape of its binding pocket or altering molecular dynamics that facilitate ligand recognition or channel opening.
It is established that zinc inhibits thioredoxin reductase, for example [ 150], and this could perturb antioxidant defences linked to thioredoxins.
Thus, it is possible that the kisspeptin/GPR54 neurosecretory system is a target through which EDCs could perturb normal reproductive function (Navarro and Tena-Sempere 2008).
Differential evolution (DE) benefits from its differential operators, namely mutation operator and crossover operator, which could perturb multiple variables simultaneously and has shown a fast convergence speed.
Thus, identification of small molecules that could perturb the interaction between AEG-1 and its partners, resulting the inhibition of AEG-1 function, might be a rational and effective way of target therapy of NSCLC.
What in the environment could perturb their reproduction?
He meant that Taylor's letter could perturb his host, Nigeria's President, Olusegun Obasanjo, who believes that he deserves much of the credit for getting Taylor out of Liberia, and who is under some international pressure to hand Taylor over to Sierra Leone, where he has been indicted for war crimes.
MJ and SA treatment changes medium acidification, which could perturb the equilibrium between the intracellular and extracellular compartments.
Given their available computing resources, they could perturb only one parameter at a time for a total of 53 simulations.
In vitro studies demonstrated that miR-224 could perturb cumulus expansion in EGF-stimulated COCs by decreasing PTX3 secretion.
