The determination of the structure of this novel mycobacterial drug target will now allow the targeting of specific residues that could impair its function.
Any attempt to decorate the unit could impair its function.
In this study, we detected misfolded tau in a significant fraction of presynaptic and postsynaptic terminals in AD subjects, which had two significant functional implications: (1) it could impair brain network function; (2) it could represent the anatomical substrate of tau synaptic transmission.
On the other hand, it remains possible that PrPSc accumulation could impair proteasome function and peptide presentation by MHC I [19].
It is tempting to speculate that PINK1 mutations could impair the function of the UPS.
They suggested that for the replenishment of water and sodium, isotonic saline was likely to be inferior to balanced crystalloid solutions as it contained very high concentration of chloride, which could impair renal function.
Despite the advantages of this model, humanized mice are onerous and they still present biological constraints that could impair the proper function of its immune response, i. e., innate immunity defects such as decrease in macrophage function [ 37] and the lack of human-specific adhesion molecules to improve appropriate traffic of human cells [ 38].
It not only protects the brain from agents in the blood that could impair neurological function, but also controls the influx and efflux of numerous substances to maintain proper homeostasis and provide the brain with necessary nutrients.
In a laboratory, they found that melamine and cyanuric acid may react with one another to form crystals that could impair kidney function.
If protein deposits and tangles appear in the hippocampus area of the brain, for instance, then they would affect short-term memory; appearance in the frontal lobes could impair executive function, and in the cerebellum coordination and balance.
However, current drugs used to prevent rejection could impair renal function, principally in recipients with low pretransplant estimated glomerular filtration rate (ie, <60 mL/min).
