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If you look at Gartner's research, the No. 1 IT spend trend for 2009 is IT consolidation and virtualization.
Some enterprise IT consolidation afoot, and a sign of the business crunch that the enterprise market has witnessed in the last year.
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Results of Y-IT consolidation following alternative chemotherapy (fludarabine mitoxantrone combination) are suggestive of similar efficacy.
This study preliminarily addressed the relevant question of whether Y-IT consolidation would perform well after rituximab-containing induction regimens.
Patients were assigned to either receive Y-IT consolidation or just be observed, with progression-free survival being the primary end-point.
Studies are comparing the use of Y-IT consolidation with the anti-CD20 antibody rituximab maintenance, which is also gaining acceptance.
Applying Y-IT consolidation to a group of 61 patients with follicular NHL after treatment with 6 cycles of oral fludarabine and mitoxantrone resulted in a 96% overall response rate.
Further evidence is provided by a phase 2 study of 3-cycle rituximab-CHOP induction chemotherapy given to patients with symptomatic or bulky untreated follicular NHL followed by Y-IT consolidation supplemented by 4 additional rituximab infusions.
Accordingly, it is conceivable that a successful future strategy for follicular NHL may include an induction chemotherapy regimen followed by Y-IT consolidation, to be followed by rituximab maintenance; this remains an intriguing research question for the future.
In mantle cell lymphoma, the sequence CHOP-rituximab followed by Y-IT consolidation has been tested as first-line treatment in 56 patients by the Eastern Cooperative Oncology Group (ECOG).
Along those lines, as rituximab maintenance is gaining acceptance, a subsequent multicenter randomized study is underway, comparing RIT consolidation to rituximab mainenance, or assessing the benefit of the addition of Y-IT consolidation on chemoimmunotherapy followed by rituximab maintenance backbone.
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