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If one of the subtargets is partially or totally occluded, it can be localized by knowing the position of the others.
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For example, it has been demonstrated that Rb can be localized in mitochondria and also shown that it is involved in inducing apoptosis (Hilgendorf et al., 2013).
It is known that long UTRs can be localized antisense to adjacent genes on the opposite strand; in fact some of these overlapping UTRs have been demonstrated to act as negative regulators for genes encoded on the opposite strand [ 20].
Protein phosphorylation, instead, may occur locally because protein kinase can be localized by its affinity to chromatin proteins.
It has also been shown that Akt can be localized to mitochondria and can phosphorylate the β-subunit of ATP synthase [39], [40].
This is the case for protein localization, where proteins can be localized to many distinct compartments, e.g. nucleus, ER, Golgi, cytoplasm, membrane and mitochondria.
It shows an approach to small cell which can be localized in edge cloud computing.
It is possible, however, that the tumor suppressors can be localized in a region showing chromosomal amplification in tumor cells.
By calculating the probabilities of the different hypotheses, the crack can be localized and its depth can be determined.
Recently, it has been shown that mitochondrial thioredoxin reductase (TR3) can be localized to the cytosol through alternative splicing [66].
Febrile illness can be localized to organ systems or non-localized, commonly referred to as acute undifferentiated febrile illness (AUFI).
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