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Due to the wealth of data needed to parameterize a biochemical model, it can be difficult to extend the model with new experimental findings.
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So when the basic Broadway lineup starts to feel tired, it can be difficult to navigate theater options that extend beyond seeing "Wicked" for the fourth time.
"It can be difficult to quit.
Although the fluorescence intensity of fluorescein can be controlled by structural changes, λmax and λem are difficult to extend while preserving high brightness.
Convergent approaches are difficult to extend to higher-generation dendrimers.
Despite being best known for short stories that seldom extend beyond five pages, he is a high-minded artist who can be difficult to digest.
We can be difficult to deal with.
"Keyboards can be difficult to use.
They can be difficult to find.
Lipstick palms can be difficult to grow.
Beck can be difficult to get to.
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