Exact(3)
But light also plays another role in sleep: it can acutely enhance alertness and performance during both the day and the night.
It can acutely attenuate pulmonary vascular resistance in spontaneously hypertensive fawn-hooded rats, monocrotaline-induced pulmonary hypertension in rats, and hypoxia-induced pulmonary hypertension in mice [ 81].
Hypoxia-induced pulmonary hypertension is also a major cause of morbidity in high altitude residents, where it manifests in chronic and subacute mountain sickness, while in non-residents it can acutely precipitate high altitude pulmonary oedema, the most common cause of death related to high altitude (Hackett & Roach, 2001; Penaloza & Arias-Stella, 2007).
Similar(57)
So when holding down a job, being a breadwinner, and providing for your family is the barometer of "being a man," it can be acutely difficult to deal with things going wrong.
In the absence of functional small LNv, the high amplitude morning startle response component persists in LD indicating that it can be acutely light driven, but disappears immediately upon transition into DD and is thus clock- and small LNv dependent in the absence of light.
Moreover, it can also acutely enhance circulating levels of triglycerides in rats (Nonogaki et al. 1995), suggesting the importance of this cytokine in APR-induced metabolic disorder.
It can present acutely with rapid onset and a fluctuating short-term course such as delirium, or as a chronic illness with a gradual, progressive course, for example mild cognitive impairment (MCI) and dementia.
These studies demonstrate that testosterone and its analogs can acutely modify the cardiac AP and underlying ionic currents, although whether these effects are relevant in vivo is unclear because most studies used supra-physiological concentrations of drug.
Such an association has yet to be defined for type 1 diabetes; however, because hyperglycemia can acutely alter normal homeostasis, it is reasonable to hypothesize that this effect will be accentuated in any individual with diabetes.
Given the multitude of effects of Ras and ErbB2 transformation on cell signaling, it is somewhat surprising that PKCι knockdown or chemical inhibition can acutely reverse (albeit partially) the abnormal non-polarized epithelial morphology but this is particularly interesting in the context of potential therapeutic interventions.
It has recently been shown that an oral glucose load of 75 g can acutely lower total testosterone concentrations by 25% (23).
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Justyna Jupowicz-Kozak
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