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In addition, it binds strongly to hydroxyapatite.
And it binds strongly to a protein found in the blood, which could lead to side effects in humans.
Domperidone is a dopamine antagonist in vitro; it binds strongly to the dopamine (DA) receptors of the striatal area [ 40].
It is a linear ionic agent, which binds strongly to albumin, limiting its diffusion into the extravascular space [59].
In addition, the MSL-complex binding profile clearly shows that it binds most strongly towards the 3' end of genes [ 19].
It binds more strongly to active CYCD2/CDKA 1 and CYCD2/CDKB2 1 complexes than to their monomer components [87].
This was unsurprising, since full length D.m.H binds rather weakly to Gro, whereas it binds very strongly to a short peptide containing the GBD [ 12].
Interestingly, we found that SAP130 binds with similar affinity to Cul1, Cul4 and Cul2; while it binds more strongly to Cul3 (Fig. 4A).
The compound also failed to show specificity in SPR as it binds equally strongly to pure AT sequences (Table 1).
This showed that while AZD9773 bound strongly to hTNFα, it did not bind above background levels to mTNFα.
In that time, one hormone receptor changed so that it bound most strongly to cortisol, a stress hormone.
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