For example, INK4-ARF is silenced in embryonic, fetal, and adult stem cells, but in more differentiated cells, it becomes poised for expression and increasingly responsive to aberrant mitogenic signals such as those elicited by activated oncogenes (reviewed in Sherr, 2012).
Breakthroughs in genetics have often raised complex ethical and legal questions, which loom ever larger as genetic testing is becoming more commonplace, affordable, and comprehensive, and genetic editing becomes poised to be a consumer technology.
The move signals a possible shift in care of late-stage breast cancer, as a new class of drugs becomes poised to challenge tamoxifen.
As described above, the INK4-ARF locus is also transcriptionally silenced in undifferentiated hESCs and becomes poised for expression following differentiation (Sherr, 2012).
As a consequence, cells became poised and more susceptible to sense and use other electron acceptors that were encountered.
Mountains will be reduced to hills, and hills to level ground as all children become poised for life choices that can compete with their imaginations.
Arizona became poised to take the lead after Gary Brightwell exploded past the defense, tearing down the middle of the field for a 72-yard rush.
It is established that enhancer elements acquire H3K4me1 and H3K27ac coincident with their developmental activation at this point, while others become poised and enriched for H3K27me3 (Buecker et al., 2014; Factor et al., 2014).
Operating at this scale, where the naked eye is rendered useless by the precision of our machines, it becomes clear that we are poised for a future where the analog and digital dichotomy is nothing more than an exercise in perspective taking.
As the SNP soared in the polls, it became clear she was poised to unseat Labour heavyweight Douglas Alexander.
If "Don 2″ continues its strong streak, it's poised to become one of the top grossing Bollywood films in North America of all time ("3 Idiots" at $6.5 million and "My Name is Khan" at $4 million currently hold the honors).
