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However, it becomes difficult to select the best primers since they do not provide information regarding the specificity of the oligonucleotides or patterns [131] [134].
Applying any optimization technique (e.g., SVM) prior to applying a feature selection method can result in the "curse of dimensionality" (e.g., a large number of features where it becomes difficult to select the representative features that are the basis for any base classification algorithm).
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Unfortunately, with the proliferation of systematic reviews on the same topic, it becomes difficult to make informed decisions regarding the effects of various interventions on selected outcomes.
It becomes difficult to maintain faith.
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However, it becomes difficult to see the patterns described above.
Energy consumption becomes very crucial when it comes to underwater, as it becomes difficult to replace/charge the sensor nodes.
It becomes difficult to ignore such kind of special offers.
1) It becomes difficult to experience dependency without shame.
It becomes difficult to move.
My sense of taste changes, it becomes difficult to eat.
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