Sentence examples for it abrogates the from inspiring English sources
In the case of FOXP3 the loss of exon 2 eliminates some of its repressor function, as it abrogates the interaction with RORγt, the transcription factor driving the differentiation towards Th17 [14].
In addition, Snail1 has recently been shown to activate Wnt/β-Catenin signaling and Nuclear factor kappa B activity [7], [8], and it abrogates the inhibition of Wnt/β-Catenin pathway caused by the antitumoral compound 1α,25-dihydroxyvitamin D3 [9].
Although knockdown of CHOP does not prevent TRAIL-induced apoptosis, it abrogates the potentiation of TRAIL-induced apoptosis by salubrinal.
It abrogates the formation of ergosterol by inhibiting squalene epoxidase, the catalytic enzyme responsible for converting squalene to 2,3-oxidosqualene (an ergosterol precursor).
Snail1 has recently been shown to activate Wnt/beta-Catenin signalling and nuclear factor kappa B activity [ 8, 9], and it abrogates the inhibition of the Wnt/beta-Catenin pathway caused by the anti-tumoural compound 1a,25-dihydroxyvitamin D3 [ 10].
For example, it abrogates the phorbol-12-myristate-13-acetate phorbol-12-myristate-13-acetate phorbol-12-myristate-13-acetate phorbol-12-myristate-13-acetate phorbol-12-myristate-13-acetate-κB), inhibits ePMAermal growth factor receptor tyrosine kinase, insulin receptors and protein kinase C and reduces synthesis of prostaglandin-E2 and intumorukinecrosis 5– 8].
However, when Mss4 was co-expressed with eIF3f, it abrogated the suppressive function of eIF3f.
Moreover, it abrogated the stimulation conferred by insulin-like growth-factor-1, a mechanism relevant for MM progression.
Importantly, when we mutated the highly conserved putative miR-23a target site within TRF2 3′UTR, it abrogated the ability of miR-23a to negatively regulate TRF2 expression.
MIBE did not show any capability to transactivate ERα; however, it abrogated the luciferase activity induced by E2 like the ER antagonist OHT.
When the PPAY motif within spartin was mutated to PAAA, it abrogated the interaction with AIP5 and AIP4 ([ 5, 8] and this study).
