Exact(1)
We focused on the cell cycle inhibitor CDKN1A mRNA, and in a quantitative PCR validation experiment, we demonstrated that CDKN1A expression was significantly lower in ALL samples with low JQ1 EC50 values, whereas it's upstream negative regulator MYC was significantly higher in the same category of leukaemias.
Similar(59)
An AROR was considered "adjacent" to a RefSeq feature if it was within the annotated gene or one of its introns, or if it was upstream or downstream of the gene with no other intervening genes.
"The idea behind this is that it is upstream intervention, which actually saves the NHS and social services money.
Indeed, release of vasoactive or hormonal substances can only lead to downstream adaptation, but it is upstream adaptation that is required.
Due to it is upstream of thrombin, FXa can promote the production of new thrombin without causing bleeding symptoms or affecting the existing thrombin [3].
To ease the transition away from oil, transportation carbon should be priced, whether it is upstream at the producers or downstream at the pump.
In most cases, it is upstream of the glyQ (glycyl-tRNA synthetase subunit alpha) gene.
It is upstream of nlpD, a putative peptidase, and thus might affect its expression.
For example, an alternative START is unlikely to be used if it is upstream of the ribosome binding site.
eNOS activation is essential for mediating the protective effects of statins, and it is upstream of COX2 activation [ 33].
A yeast upstream activating sequence (UAS) is similar to enhancers in other organisms, except that it affects transcription only when it is upstream of a gene.
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