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"It's substitute insulin," agrees Satya Kalra, a neuroscientist at the University of Florida in Gainesville who did the earlier gene therapy work with leptin.
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Glu 153, another adenine-contacting position, is fully conserved except for two cases where it is substituted with glutamine and one case with aspartate, both fairly conservative substitutions.
Interestingly, pSer16 is conserved across rice G6PD orthologs, but it is substituted with a non-phosphorylatable Asn residue in its Arabidopsis and Medicago orthologs.
"It was substituted by a lottery mentality.
When a component receives such message, it is substituted by the new version.
Once Var(S * was computed from Eq. (6), then it was substituted for Var(S) in Eq. (5).
Once J is found, it is substituted into Eq. (6) to estimate the geoelectric field on the ground.
Everywhere you see the word "black," it was substituted for "woman" in the original context.
As plutonium was not available, it was substituted with material with similar mechanical properties.
Fortunately, the entrance chorus from Thespis fitted the situation almost exactly, so it was substituted instead.
The Zeebad Gonabad water clock was in used until 1965 when it was substituted by modern clocks.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com