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Furthermore, it is problematic to differentiate the particle from the background fluorescence.
A significant source of false-positives for this method comes from the fact that dual out-edges can be created by genome structure that is not just a SNP- any pair of k-mers that differ by a single end nucleotide causes the key bifurcation thus repeats, inversions and other low-complexity genome sequence can be problematic to differentiate from the desired SNPs.
It is tough to differentiate legitimate good links from bad.
Thus it is problematic to analyze allelic SNPs in B. napus as it is difficult to differentiate SNPs from the much more abundant inter-homoeolog polymorphisms (IHPs).
It is problematic to standardise products not fully developed.'.
It was problematic to say the least.
Thus, it is problematic to analyze their results together.
Therefore, it would be problematic to demand compliance.
To say it's problematic is putting it lightly.
"Obviously, it's problematic".
And it's problematic".
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