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At its best in the Loire and Bordeaux, where it's long established and where winemakers know how to retain some leafy freshness, many of the examples I've tried from South Africa have been syrupy and dull.
In the same way, it's long established that the government has great latitude in intercepting communications between the United States and other countries.
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It was "long established government policy neither to confirm nor deny speculation of this sort", he wrote.
While it was long established that riboswitch aptamers are modular and portable, capable of directing different output domains including ribozymes, switches, and fluorophore-binding modules, the same has not been demonstrated until recently for expression platforms.
Many genes buffer genetic variation through extensive epistatic interactions [49]; it is long established that the phenotypes of developmental mutations are more variable than the wild-type [42].
It is long established that mutations in early components of the classical pathway strongly associate with lupus susceptibility in humans and mice (reviewed in Elkon and Santer, 2012).
In conventional mono-chemotherapy, it was long established that patients became less sensitive over the treatment courses as their cancers acquired resistance to the drug.
There are currently no MND-specific scales for measuring fatigue and it is long established that generic questionnaires may be insensitive to the unique experience of a patient with MND [ 5].
It has been long established that even most active fund managers fail to beat the overall market on a regular basis.
Geographer Jeremy Crampton suggests that not doing so could lead to dire consequences: "It has been long established that the sky is public – otherwise each airplane would have to get permission to fly over your property.
It has been long established that the governing deformation mechanism for Si under such contact loading conditions is stress induced phase transformation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com