All the protein web tools used (SIFT, PolyPhen, MAPP-MMR [ 20]) conclude that it is a deleterious change.
It was a deleterious network that decreased coronary blood flow exacerbating ischemia-induced myocardial stiffness when spontaneously coupled with the gradual rising right atrial pressure further precluded coronary perfusion.
The class of a substitution is determined by the effect of the substitution on the phenotype when there are no other substitutions in the genotype: A substitution which retains the phenotype is a neutral substitution; otherwise it is a deleterious substitution.
Secondly, P1606S occurred at a very low frequency at 44 DPI followed by nondetection in 57 DPI (perhaps due to extremely low frequency of occurrence), indicating the possibility that it is an individual deleterious mutation, which restricts the fitness or success of the escape variant.
The mutational-burden hypothesis asserts that noncoding DNA (i.e., intronic and intergenic DNA) is a genetic liability because it is a target for deleterious and potentially lethal mutations, such as mutations affecting sequences involved with intron splicing and gene regulation.
In his view, Drake "was just saying, 'We're not doing our job, and it's having a deleterious effect on mission performance.' He was right, by the way".
Thirty-five per cent say that it was just another episode in the struggle for power among the top leadership, while thirty per cent think that it was a tragedy that had deleterious effects on the state and the people.
The bacteriological examination of water has a special significance in pollution studies, as it is a direct measurement of deleterious effect of pollution on human health.
14, 15 After an extensive literature review seeking information regarding the impact of melasma on health-related QoL in affected patients, it was determined that there was a deleterious impact on social life, emotional well-being, physical health, and financial status in Hispanic women.
Although leaf senescence is a deleterious process, it is crucial for the fitness of plants; efficient senescence is essential to maximize viability during the plant's life cycle.
Although the L35P mutant has not yet been identified in ALS patients, from the simulation results using the ANGDelMut web-tool, it seems that L35P would possibly be a deleterious mutation.
