Sentence examples for issues substantial from inspiring English sources

To obviate these issues, substantial efforts have been made to design non-peptidic small molecules with neurotrophin-like activities.

Even regions that are unlikely to issue substantial amounts of new debt — like South America and Eastern Europe — will be affected by rising rates as they refinance their existing debt.

That structure involved issuing substantial amounts of stock to company founders and consultants, like Mr. Pace, at very low prices before the public offerings.

This issue has substantial effect on older adults to lose their appeal to adopt smart home technology.

"These unsettled issues are substantial and of potentially widespread significance," the tour's lawyers wrote in seeking the extension.

"With large numbers of people in close proximity to a major hazard pipeline, our view is that the proposed development raises safety issues of substantial concern.

From a questionnaire-based survey, Portuguese household level data are used to show that average measures can mask affordability issues for substantial proportions of the low income groups.

The issues of substantial equivalency protections to federal protected classes and the need for state protection of LGBT have now fused.

JB/TT - expert respiratory input contribution to study conceptualisation and refining on outcome measures, statistical issues and substantial contribution to writing up of the protocol for publication.

The general consensus is that this paper is in principle appropriate for eLife as it is novel and addresses issues of substantial general interest.

Nevertheless, targeted effectively, MURs have the potential to reveal important medicines and health related issues with substantial impact on healthcare outcomes.