I hope that you will soon address the public health issue represented by a dysfunctional system for bringing new drugs and therapies to market.
Domestically, the dog that didn't bark throughout this campaign was the issue represented by the twin failures of the bridge in Minneapolis and the levees in New Orleans -- both the result of design failures.
Half of the 56 bond issues represented in the portfolio are not covered by rating agencies.
These issues represented aspects of the patients' medical history that needed to be addressed by the physicians, such as depression, review of lifestyle or therapy, and compliance issues.
In case of airfoils rotating around an axis orthogonal to flow direction, one of the most critical issues is represented by the definition of the incidence angle on the airfoil from the computed flow field.
Other critical issues are represented by in vitro T-cell culture methods when immune responses are analyzed in expanded T-cell cultures instead of ex vivo.
A way of circumventing these issues is represented by the direct administration of recombinant bacteria, acting simultaneously as cell factory and delivery system for pharmacologically active proteins.
In fact, critical issues are represented by nonuniform sample choice, handling, and processing, as well as by blood cell contamination in sample preparation and lack of consensus for data normalization.
The key technical issue is represented by use of large catheters (>6 French) [2, 3].
A final issue is represented by time required to the clinician to acquire sufficient competence in critical care ECHO.
