Sentence examples for issues of the initial from inspiring English sources

Several issues of the initial lead structures had to be resolved, such as potency, selectivity over related GPCRs and P-gp efflux limiting brain exposure in this series.

During optimization several issues of the initial lead structures had to be resolved, such as selectivity over related GPCRs, inhibition of the hERG channel as well as the potential to induce phospholipidosis.

On the issue of the initial creation, Ditko states, "I still don't know whose idea was Spider-Man".

It is noted that the proposed approach does not address the identifiability issue of the initial states which would be a future research aspect.

"I think it settles the issue of whether the initial report was real or not," said K. Kimberly McCleary, president of the CFIDS Association of America, the leading organization for people with chronic fatigue syndrome.

The first issue of generating the initial path is relatively easy to address.

Mike Mitchell, an analyst at the stockbroker Panmure Gordon, said: "With these sorts of issues, the initial reaction is usually overstated compared with what comes to pass in due course but it brings investors and the market back to thinking about the price differential between the US and European markets.

But Ned Desmond, the magazine's managing editor, said the combined issue was part of the initial publication plan and should not cause too much concern.

A number of administrative issues occurred during the initial implementation of the fruit and vegetable vouchers.

109 such re-wears were issued, accounting for 15.3% of the initial 714 issues of accelerometers and bringing the total number of accelerometer issues to 823.

The time between the two interviews varied from one to two months to allow time for settling the understanding of ethical issues within the initial encounter.